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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| TROVAFLOXACIN DISCONTINUED (is an active metabolite)
| TROVAFLOXACIN | ANTIINFECTIVES | ORAL | Cmax 2.4 MICROMOLAR (100 MILLIGRAM) VD 84.5 LITER (65 KILOGRAM) PPB 76 PERCENT Cl 5.4 LITER / HOUR (65 KILOGRAM) HT 9 HOUR | DNA GYRASE SUBUNIT A DNA TOPOISOMERASE 4 SUBUNIT A DNA TOPOISOMERASE 2-ALPHA PDB 4Z53 (QUINOLONE(TROVAFLOXACIN)-DNA CLEAVAGE COMPLEX OF TOPOISOMERASE IV FROM S. PNEUMONIAE) LIGAND CODE = TR6 (link to the list of PDB complexes) Download experimental 3D coordinates of TR6 with added hydrogens | Topoisomerase IV UNIPROT P0AFI2 parC -- DNA gyrase UNIPROT P0AES4 gyrA more at DrugCentral | EMA | |||
