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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
EMEDASTINE DISCONTINUED

EMEDASTINE


ATC S01GX06

ALLERGIC CONJUNCTIVITIS
SENSORY
ANTAGONIST
ANTIHISTAMINE
ANTIALLERGIC
H2 (KI=49 NANOMOLAR)
H3 (KI=12 NANOMOLAR)
DEVOID OF EFFECTS ON ADRENERGIC, DOPAMINERGIC AND SEROTONIN RECEPTORS

OPHTHALMIC

Cmax 1.6 NANOMOLAR (MAXIMUM QUANTIFIED)

HT 3.5 HOUR

SOLUBILITY WATER SOLUBLE FINE POWDER

HISTAMINE H1 RECEPTOR (KI=1.3 NANOMOLAR)

Histamine H1 receptor UNIPROT P35367 HRH1

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