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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| PAMIDRONATE
| PAMIDRONATE | MUSCOLO-SKELETAL SYSTEM | INJECTION | Cmax 11.1 MICROMOLAR F 54 PERCENT VD 258 LITER (EQN) Cl 6.4 LITER / HOUR HT 28 HOUR SOLUBILITY SOLUBLE IN WATER | FARNESYL PYROPHOSPHATE SYNTHASE PDB 5ERO (CRYSTAL STRUCTURE OF ELONGATION DOMAIN OF PHOMOPSIS AMYGDALI FUSICOCCADIENE SYNTHASE COMPLEXED WITH COBALT IONS AND PAMIDRONATE) LIGAND CODE = 210 (link to the list of PDB complexes) Download experimental 3D coordinates of 210 with added hydrogens | Farnesyl pyrophosphate synthase UNIPROT P14324 FDPS more at DrugCentral | EMA | |||
