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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| NICOTINE
| NICOTINE | NATURAL MOLECULE (link) NERVOUS SYSTEM | BUCCAL TRANSDERMAL NASAL ORAL | Cmax 55 NANOMOLAR F 53 PERCENT (INHALATED) VD 162 LITER (65 KILOGRAM) PPB 5 PERCENT Cl 72 LITER / HOUR HT 1.5 HOUR SOLUBILITY SOLUBLE | ACETYLCHOLINE RECEPTOR PDB 5KXI (X-RAY STRUCTURE OF THE HUMAN ALPHA4BETA2 NICOTINIC RECEPTOR) LIGAND CODE = NCT (link to the list of PDB complexes) Download experimental 3D coordinates of NCT with added hydrogens | Neuronal acetylcholine receptor more at DrugCentral | EMA | |||
