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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| MORPHINE
| MORPHINE | NATURAL MOLECULE (link)
NERVOUS SYSTEM | INJECTION ORAL INTRAMUSCULAR EPIDURAL INTRAVENOUS | Cmax 273 NANOMOLAR F 40 PERCENT VD 227 LITER (65 KILOGRAM) PPB 27 PERCENT Cl 97.5 LITER / HOUR (65 KILOGRAM) HT 2 HOUR SOLUBILITY SOLUBLE IN WATER | MU-TYPE OPIOID RECEPTOR PDB 1Q0Y (ANTI-MORPHINE ANTIBODY 9B1 COMPLEXED WITH MORPHINE) LIGAND CODE = MOI (link to the list of PDB complexes) Download experimental 3D coordinates of MOI with added hydrogens | Mu-type opioid receptor UNIPROT P35372 OPRM1 more at DrugCentral | EMA | |||
