PRIMAQUINE | PRIMAQUINE | ATC P01BA03
ANTIPARASITIC ANTIMALARIAL ANTIPROTOZOAL AGENTS CAPABLE OF CLEARING THE INTRA-HEPATIC SCHIZONTS AND HYPNOZOITES OF PLASMODIUM VIVAX PRECIPITATE HAEMOLYSIS IN GLUCOSE-6-PHOSPHATE DEHYDROGENASE (G6PD) DEFICIENT INDIVIDUALS GAMETOCYTOCIDAL AGENT IN FALCIPARUM MALARIA INTERFERE WITH THE CELLULAR RESPIRATION OF THE PARASITE BY GENERATING OXYGEN FREE RADICALS AND DEREGULATING THE ELECTRON TRANSPORT | ORAL | Cmax 16 NANOMOLAR (15 MILLIGRAM / DAY , PMID3542534) VD 292 LITER Cl 37.6 LITER / HOUR HT 5.6 HOUR | PDB 4FGJ (OXIDIZED QUINONE REDUCTASE 2 IN COMPLEX WITH PRIMAQUINE) LIGAND CODE = 1PQ (link to the list of PDB complexes) Download experimental 3D coordinates of 1PQ with added hydrogens | Unknown more at DrugCentral | EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank |