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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| BICALUTAMIDE
| BICALUTAMIDE | ANTINEOPLASTIC | ORAL | Cmax 1.78 MICROMOLAR VD 64 LITER (EQN) PPB 96 PERCENT Cl 0.32 LITER / HOUR HT 139 HOUR SOLUBILITY PRATICALLY INSOLUBLE IN WATER AT 37 DEGREE CELCIUS 5 MICROGRAM / MILLILITER | ANDROGEN RECEPTOR PDB 4OKT (CRYSTAL STRUCTURE OF W741L-AR-LBD BOUND WITH CO-REGULATOR PEPTIDE) LIGAND CODE = 198 (link to the list of PDB complexes) Download experimental 3D coordinates of 198 with added hydrogens | Androgen receptor UNIPROT P10275 AR more at DrugCentral | EMA | |||
