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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
TERAZOSIN

TERAZOSIN


ATC G04CA03

GENITO
BENIGN PROSTATIC HYPERPLASIA
ANTIHYPERTENSIVE
ALPHA-1-SELECTIVE ADRENOCEPTOR BLOCKING AGENT

ORAL

Tmax 1 HOUR

VD 58 LITER

PPB 99 PERCENT

Cl 4 LITER / HOUR

HT 12 HOUR

SOLUBILITY FREELY SOLUBLE IN WATER

ALPHA-1 ADRENERGIC RECEPTOR

PDB 4O33 (CRYSTAL STRUCTURE OF HUMAN PGK1 3PG AND TERAZOSIN(TZN) TERNARY COMPLEX)

LIGAND CODE = TZN (link to the list of PDB complexes)

Download experimental 3D coordinates of TZN with added hydrogens

Alpha-1A adrenergic receptor UNIPROT P35348 ADRA1A -- Alpha-1D adrenergic receptor UNIPROT P25100 ADRA1D

more at DrugCentral

EMA

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