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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
MICONAZOLE

MICONAZOLE


ATC A01AB09
ATC A07AC01
ATC D01AC02
ATC G01AF04
ATC J02AB01
ATC S02AA13
ATC D01AC52

METABOLISM
ANTIFUNGAL (TOPICAL)
CYTOCHROME P450 14ALPHA-DEMETHYLASE INHIBITOR
INHIBITION OF ERGOSTEROL SYNTHESIS (FUNGAL CELL MEMBRANE)

VAGINAL TOPICAL INJECTION BUCCAL

Cmax 36 MICROMOLAR

PPB 88 PERCENT

HT 24 HOUR

CYTOCHROME P450 14ALPHA-DEMETHYLASE

Lanosterol 14-alpha demethylase UNIPROT P10613 ERG11

more at DrugCentral

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