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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| MITOTANE
| MITOTANE | ANTINEOPLASTIC | ORAL | Cmax 44.7 MICROMOLAR F 40 PERCENT HT 2124 HOUR | SXR RECEPTOR | Cytochrome P450 11B1, mitochondrial UNIPROT P15538 CYP11B1 -- Cholesterol side-chain cleavage enzyme, mitochondrial UNIPROT P05108 CYP11A1 more at DrugCentral | EMA | |||
