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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ETHOSUXIMIDE
| ETHOSUXIMIDE | NERVOUS SYSTEM | ORAL | Cmax 496 MICROMOLAR Tmax 5 HOUR VD 45.5 LITER (65 KILOGRAM) PPB 0 PERCENT HT 60 HOUR | VOLTAGE-DEPENDENT CHANNEL PDB 5OH3 (CEREBLON ISOFORM 4 FROM MAGNETOSPIRILLUM GRYPHISWALDENSE IN COMPLEX WITH ETHOSUXIMIDE) LIGAND CODE = 9V2 (link to the list of PDB complexes) Download experimental 3D coordinates of 9V2 with added hydrogens | Voltage-dependent T-type calcium channel subunit alpha-1G UNIPROT O43497 CACNA1G more at DrugCentral | EMA | |||
