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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| PROMETHAZINE
| PROMETHAZINE |
RESPIRATORY | ORAL INJECTION RECTAL | VD 910 LITER (65 KILOGRAM) PPB 91 PERCENT Cl 54 LITER / HOUR (65 KILOGRAM) HT 14 HOUR SOLUBILITY FREELY SOLUBLE IN WATER | HISTAMINE H1 RECEPTOR PDB 7MQU (THE HADDOCK MODEL OF GDP KRAS IN COMPLEX WITH PROMETHAZINE USING NMR CHEMICAL SHIFT PERTURBATIONS) LIGAND CODE = ZM7 (link to the list of PDB complexes) Download experimental 3D coordinates of ZM7 with added hydrogens | Histamine H1 receptor UNIPROT P35367 HRH1 more at DrugCentral | EMA | |||
