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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| IVERMECTIN
| IVERMECTIN | ANTIPARASITIC | ORAL TOPICAL | Cmax 53 NANOMOLAR Tmax 4 HOUR PPB 99 PERCENT HT 18 HOUR SOLUBILITY INSOLUBLE IN WATER | GLYCINE RECEPTOR (GLYR) GLUTAMATE-GATED CHLORIDE CHANNEL GABA RECEPTOR NS3 HELICASE (PMID22535622) PDB 3JAF (DANIO RERIO ALPHA-1 GLYCINE RECEPTOR BY CRYO-EM) LIGAND CODE = IVM (link to the list of PDB complexes) Download experimental 3D coordinates of IVM with added hydrogens | Glutamate-gated chloride channel UNIPROT P91730 -- Glutamate-gated chloride channel UNIPROT Q25634 GluClX more at DrugCentral | EMA | |||
