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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| TACROLIMUS
| TACROLIMUS | IMMUNOMODULATING AGENT | ORAL INJECTION TOPICAL | Cmax 36.9 NANOMOLAR F 18 PERCENT VD 126.1 LITER (65 KILOGRAM) PPB 99 PERCENT Cl 2.6 LITER / HOUR (65 KILOGRAM) HT 34.8 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | FKBP-12 PDB 3O5R (COMPLEX OF FK506 WITH THE FK1 DOMAIN MUTANT A19T OF FKBP51) LIGAND CODE = FK5 (link to the list of PDB complexes) Download experimental 3D coordinates of FK5 with added hydrogens | Peptidyl-prolyl cis-trans isomerase FKBP1A UNIPROT P62942 FKBP1A more at DrugCentral | EMA | |||
