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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| MEROPENEM
| MEROPENEM | ANTIINFECTIVES | INJECTION INTRAVENOUS | Cmax 127.9 MICROMOLAR VD 19.5 LITER (65 KILOGRAM) PPB 2 PERCENT Cl 15.2 LITER / HOUR (65 KILOGRAM) HT 1 HOUR SOLUBILITY SPARINGLY SOLUBLE IN WATER | PENICILLIN-BINDING PROTEIN (PBP) PDB 4EUZ (CRYSTAL STRUCTURE OF SERRATIA FONTICOLA CARBAPENEMASE SFC-1 S70A-MEROPENEM COMPLEX) LIGAND CODE = MEM (link to the list of PDB complexes) Download experimental 3D coordinates of MEM with added hydrogens | D-alanyl-D-alanine carboxypeptidase DacB UNIPROT P24228 dacB more at DrugCentral | EMA | |||
