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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| CLAVULANATE
| CLAVULANATE | ANTIINFECTIVES | ORAL INJECTION | Cmax 12 MICROMOLAR (125 MILLIGRAM) VD 14.3 LITER (65 KILOGRAM) PPB 25 PERCENT Cl 12 LITER / HOUR (65 KILOGRAM) HT 1.0 HOUR | BETA-LACTAMASE PDB 2XFS (STRUCTURAL AND MECHANISTIC STUDIES ON A CEPHALOSPORIN ESTERASE FROM THE CLAVULANIC ACID BIOSYNTHESIS PATHWAY) LIGAND CODE = J01 (link to the list of PDB complexes) Download experimental 3D coordinates of J01 with added hydrogens | Beta-lactamase TEM UNIPROT P62593 bla, blaT-3, blaT-4, blaT-5, blaT-6 more at DrugCentral | EMA | |||
