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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| CEPHALOTHIN DISCONTINUED
| CEPHALOTHIN | ANTIINFECTIVES | INJECTION | VD 4.5 LITER (65 KILOGRAM) PPB 78 PERCENT Cl 7 LITER / HOUR (65 KILOGRAM) HT 0.95 HOUR | PENICILLIN-BINDING PROTEINS 1A/1B D-ALANYL-D-ALANINE CARBOXYPEPTIDASE BETA-LACTAMASE PDB 4KOX (CRYSTAL STRUCTURE OF A GNAT SUPERFAMILY ACETYLTRANSFERASE PA4794 IN COMPLEX WITH CEFALOTIN) LIGAND CODE = CLS (link to the list of PDB complexes) Download experimental 3D coordinates of CLS with added hydrogens | Bacterial penicillin-binding protein UNIPROT P02918 mrcA more at DrugCentral | EMA | |||
