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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
LINCOMYCIN

LINCOMYCINNATURAL MOLECULE (link)


ATC J01FF02

ANTIINFECTIVES
ANTIBACTERIAL
ANTIBIOTIC
PROTEIN SYNTHESIS INHIBITORS
A SUBSTANCE PRODUCED BY LINCOLNENSIS GROUP OF STREPTOMYCES LINCOLNENSIS

ORAL INJECTION

Cmax 39 MICROMOLAR (600 MILLIGRAM)

VD 65 LITER (65 KILOGRAM)

PPB 57 PERCENT

Cl 8.2 LITER / HOUR (65 KILOGRAM)

HT 5.4 HOUR

SOLUBILITY IS FREELY SOLUBLE IN WATER

50S RIBOSOMAL PROTEIN

PDB 5HKV (THE CRYSTAL STRUCTURE OF THE LARGE RIBOSOMAL SUBUNIT OF STAPHYLOCOCCUS AUREUS IN COMPLEX WITH LINCOMYCIN)

LIGAND CODE = 3QB (link to the list of PDB complexes)

Download experimental 3D coordinates of 3QB with added hydrogens

70S RIBOSOME INHIBITOR CHEMBL2363853 70S RIBOSOME 23S RIBOSOMAL RNA STREPTOCOCCUS PNEUMONIAEANSM (in French)

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