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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| AMPHOTERICIN B
| AMPHOTERICIN B |
ANTIINFECTIVES | TOPICAL ORAL INJECTION | Cmax 89.9 MICROMOLAR VD 6.5 LITER (65 KILOGRAM) PPB 90 PERCENT Cl 0.715 LITER / HOUR (65 KILOGRAM) HT 8.5 HOUR | MEMBRANE PDB 7SHI (CRYSTAL STRUCTURE OF CYTOCHROME P450 AMPHL FROM STREPTOMYCES NODOSUS AND THE STRUCTURAL BASIS FOR SUBSTRATE SELECTIVITY IN MACROLIDE METABOLIZING P450S) LIGAND CODE = 4UH (link to the list of PDB complexes) Download experimental 3D coordinates of 4UH with added hydrogens | Unknown more at DrugCentral | EMA | |||
