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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| PENICILLIN G
| PENICILLIN G | ANTIINFECTIVES | ORAL INJECTION INTRAMUSCULAR INTRAVENOUS | Cmax 134.7 MICROMOLAR VD 15 LITER (65 KILOGRAM) PPB 60 PERCENT Cl 24.8 LITER / HOUR (65 KILOGRAM) HT 0.7 HOUR SOLUBILITY VERY SLIGHTLY SOLUBLE IN WATER | PENICILLIN-BINDING PROTEINS 1A/1B PDB 1UOB (DEACETOXYCEPHALOSPORIN C SYNTHASE COMPLEXED WITH 2-OXOGLUTARATE AND PENICILLIN G) LIGAND CODE = PNN (link to the list of PDB complexes) Download experimental 3D coordinates of PNN with added hydrogens | Bacterial penicillin-binding protein UNIPROT P02918 mrcA more at DrugCentral | EMA | |||
