| | ||||||||||
| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ERYTHROMYCIN (is an active metabolite)
| ERYTHROMYCIN |
ANTIINFECTIVES | INJECTION OPHTHALMIC TOPICAL ORAL | Cmax 2.29 MICROMOLAR (250 MILLIGRAM ORAL) Tmax 3 HOUR VD 61.7 LITER (65 KILOGRAM) PPB 90 PERCENT Cl 21.8 LITER / HOUR (65 KILOGRAM) HT 2 HOUR | 50S RIBOSOMAL PROTEIN PDB 4M83 (ENSEMBLE REFINEMENT OF PROTEIN CRYSTAL STRUCTURE (2IYF) OF MACROLIDE GLYCOSYLTRANSFERASES OLED COMPLEXED WITH UDP AND ERYTHROMYCIN A) LIGAND CODE = ERY (link to the list of PDB complexes) Download experimental 3D coordinates of ERY with added hydrogens | Unknown more at DrugCentral | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ERYTHROMYCIN ETHYLSUCCINATE (has an active metabolite)
| ERYTHROMYCIN ETHYLSUCCINATE |
DERMATOLOGICALS | ORAL | SOLUBILITY POORLY SOLUBLE IN WATER | 50S RIBOSOMAL PROTEIN | BACTERIAL 70S RIBOSOME INHIBITOR CHEMBL2363135 BACTERIAL 70S RIBOSOME 23S RIBOSOMAL RNA BACTERIA more at DrugCentral | EMA | |||
