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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| DOXYCYCLINE
| DOXYCYCLINE | NATURAL MOLECULE (link) ANTIINFECTIVES | ORAL INJECTION PERIODONTAL | Cmax 5.8 MICROMOLAR (200 MILLIGRAM ORAL) Tmax 2 HOUR VD 44.8 LITER (65 KILOGRAM) PPB 90 PERCENT Cl 1.8 LITER / HOUR (65 KILOGRAM) HT 20 HOUR SOLUBILITY SOLUBLE IN WATER | 30S RIBOSOMAL PROTEIN 50S RIBOSOMAL PROTEIN PDB 2XRL (TET-REPRESSOR CLASS D T103A WITH DOXYCYCLINE) LIGAND CODE = DXT (link to the list of PDB complexes) Download experimental 3D coordinates of DXT with added hydrogens | Unknown more at DrugCentral | EMA | |||
