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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| PROBENECID
| PROBENECID | METABOLISM | ORAL | VD 8.4 LITER (65 KILOGRAM) PPB 97 PERCENT Cl 0.97 LITER / HOUR (65 KILOGRAM) HT 5.9 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | ORGANIC ANION TRANSPORTER PDB 8BVT (CRYO-EM STRUCTURE OF RAT SLC22A6 BOUND TO PROBENECID) LIGAND CODE = RTO (link to the list of PDB complexes) Download experimental 3D coordinates of RTO with added hydrogens | Solute carrier family 22 member 6 UNIPROT Q4U2R8 SLC22A6 -- Solute carrier family 22 member 8 UNIPROT Q8TCC7 SLC22A8 more at DrugCentral | EMA | |||
