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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
MARAVIROC

MARAVIROC


ATC J05AX09

ANTIINFECTIVES
ANTI-HIV AGENTS
ANTIVIRAL
PROTEIN-PROETIN INTERACTION INHIBITOR
CCR5 CO-RECEPTOR LIGAND
HIV-1 GP120

ORAL

Cmax 1.73 MICROMOLAR (300 MILLIGRAM TWICE DAILY ORAL)

Tmax 2.25 HOUR

F 28 PERCENT

VD 194 LITER

PPB 76 PERCENT

Cl 8.4 LITER / HOUR (EQN)

HT 16 HOUR

SOLUBILITY HIGHLY SOLUBLE IN WATER

C-C CHEMOKINE RECEPTOR TYPE 5

PDB 4MBS (CRYSTAL STRUCTURE OF THE CCR5 CHEMOKINE RECEPTOR)

LIGAND CODE = MRV (link to the list of PDB complexes)

Download experimental 3D coordinates of MRV with added hydrogens

C-C CHEMOKINE RECEPTOR TYPE 5 ANTAGONIST CHEMBL274 C-C CHEMOKINE RECEPTOR TYPE 5 P51681 C-C CHEMOKINE RECEPTOR TYPE 5 HOMO SAPIENS MEMBRANE RECEPTOR 7TM1 PEPTIDE CHEMOKINE RECEPTOR CC CHEMOKINE RECEPTORANSM (in French)

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BindingDB
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