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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| DORIPENEM DISCONTINUED
| DORIPENEM | ANTIINFECTIVES | INTRAVENOUS | Cmax 54.7 MICROMOLAR (500 MILLIGRAM) Tmax 1 HOUR VD 16.8 LITER PPB 8 PERCENT Cl 15.9 LITER / HOUR HT 1 HOUR | PENICILLIN-BINDING PROTEIN PDB 6P9C (OXA-48 CARBAPANEMASE, DORIPENEM COMPLEX) LIGAND CODE = O6P (link to the list of PDB complexes) Download experimental 3D coordinates of O6P with added hydrogens | Bacterial penicillin-binding protein UNIPROT P02918 mrcA more at DrugCentral | EMA | |||
