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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
IXABEPILONE

IXABEPILONE


ATC L01DC04

ANTINEOPLASTIC
CYTOTOXIC ANTIBIOTICS
MICROTUBULE INHIBITOR

INTRAVENOUS

Cmax 0.49 MICROMOLAR

Tmax 3 HOUR

VD 1000 LITER

PPB 72 PERCENT

Cl 39 LITER / HOUR (65 KILOGRAM)

HT 52 HOUR

BETA TUBULIN

PDB 7DAF (IXA IN COMPLEX WITH TUBULIN)

LIGAND CODE = GZX (link to the list of PDB complexes)

Download experimental 3D coordinates of GZX with added hydrogens

Tubulin beta UNIPROT P07437 TUBB

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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