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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
IXABEPILONE

IXABEPILONE


ATC L01DC04

ANTINEOPLASTIC
CYTOTOXIC ANTIBIOTICS
MICROTUBULE INHIBITOR

INTRAVENOUS

Cmax 0.49 MICROMOLAR

Tmax 3 HOUR

VD 1000 LITER

PPB 72 PERCENT

Cl 39 LITER / HOUR (65 KILOGRAM)

HT 52 HOUR

BETA TUBULIN

PDB 7DAF (IXA IN COMPLEX WITH TUBULIN)

LIGAND CODE = GZX (link to the list of PDB complexes)

Download experimental 3D coordinates of GZX with added hydrogens

TUBULIN INHIBITOR CHEMBL2095182 TUBULIN P04350 TUBULIN BETA-4A CHAIN HOMO SAPIENS STRUCTURALANSM (in French)

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