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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that the equation t1/2 = VD / Cl * 0.693 was used | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| MENTHOL
| MENTHOL | NATURAL MOLECULE (link)
MUSCULO-SKELETAL SYSTEM | TOPICAL | TRANSIENT RECEPTOR POTENTIAL MELASTATIN (TRPM8) ION CHANNEL (PMID25680765) PDB 8UXY (CONSENSUS OLFACTORY RECEPTOR CONSOR1 BOUND TO L-MENTHOL AND IN COMPLEX WITH MINI-GS TRIMERIC PROTEIN) LIGAND CODE = XUQ (link to the list of PDB complexes) Download experimental 3D coordinates of XUQ with added hydrogens | Transient receptor potential cation channel subfamily M member 8 UNIPROT Q7Z2W7 TRPM8 more at DrugCentral | EMA | ||||
