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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| TELBIVUDINE DISCONTINUED
| TELBIVUDINE | ANTIINFECTIVES | ORAL | Cmax 15.2 MICROMOLAR (600 MILLIGRAM) Tmax 2 HOUR PPB 3.3 PERCENT HT 44.5 HOUR SOLUBILITY SPARINGLY SOLUBLE IN WATER | HBV DNA POLYMERASE PDB 3QEO (S74E-R104M-D133A DCK VARIANT IN COMPLEX WITH L-DEOXYTHYMIDINE AND UDP) LIGAND CODE = LLT (link to the list of PDB complexes) Download experimental 3D coordinates of LLT with added hydrogens | Protein P UNIPROT Q9IF40 P more at DrugCentral | EMA | |||
