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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| POSACONAZOLE
| POSACONAZOLE | ANTIINFECTIVES | ORAL INTRAVENOUS | Cmax 731 NANOMOLAR (200 MILLIGRAM) Tmax 4 HOUR VD 1774 LITER PPB 98 PERCENT Cl 32 LITER / HOUR HT 37 HOUR SOLUBILITY INSOLUBLE IN WATER | LANOSTEROL 14 ALPHA-DEMETHYLASE (CYTOCHROME P450 P-45014DM) PDB 2X2N (X-RAY STRUCTURE OF CYP51 FROM TRYPANOSOMA BRUCEI IN COMPLEX WITH POSACONAZOLE IN TWO DIFFERENT CONFORMATIONS) LIGAND CODE = X2N (link to the list of PDB complexes) Download experimental 3D coordinates of X2N with added hydrogens | Lanosterol 14-alpha demethylase UNIPROT P10613 ERG11 more at DrugCentral | EMA | |||
