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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
POSACONAZOLE

POSACONAZOLE


ATC J02AC04

ANTIINFECTIVES
ANTIBIOTICS
TRYPANOCIDAL AGENTS
TRIAZOLE ANTIFUNGAL AGENT
BLOCKS THE SYNTHESIS OF ERGOSTEROL

ORAL INTRAVENOUS

Cmax 731 NANOMOLAR (200 MILLIGRAM)

Tmax 4 HOUR

VD 1774 LITER

PPB 98 PERCENT

Cl 32 LITER / HOUR

HT 37 HOUR

SOLUBILITY INSOLUBLE IN WATER

LANOSTEROL 14 ALPHA-DEMETHYLASE (CYTOCHROME P450 P-45014DM)

PDB 2X2N (X-RAY STRUCTURE OF CYP51 FROM TRYPANOSOMA BRUCEI IN COMPLEX WITH POSACONAZOLE IN TWO DIFFERENT CONFORMATIONS)

LIGAND CODE = X2N (link to the list of PDB complexes)

Download experimental 3D coordinates of X2N with added hydrogens

CYTOCHROME P450 51 INHIBITOR CHEMBL1780 CYTOCHROME P450 51 P10613 LANOSTEROL 14-ALPHA DEMETHYLASE CANDIDA ALBICANS (STRAIN SC5314 / ATCC MYA-2876) (YEAST) ENZYME CYTOCHROME P450 CYP_51 CYP_51A CYP_51A1ANSM (in French)

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