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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
PALIPERIDONE (is an active metabolite)

PALIPERIDONE


ATC N05AX13

NERVOUS SYSTEM
ANTIPSYCHOTIC
SCHIZOPHRENIA
BENZISOXAZOLE DERIVATIVES
DOPAMINE D2 RECEPTOR ANTAGONIST
SEROTONIN TYPE 2 (5HT2A) RECEPTOR ANTAGONIST

ORAL

Tmax 3 HOUR

VD 391 LITER

PPB 74 PERCENT

Cl 10.8 LITER / HOUR (EQN)

HT 25 HOUR

SOLUBILITY PRACTICALLY INSOLUBLE IN WATER

5-HYDROXYTRYPTAMINE 2A RECEPTOR
D(2) DOPAMINE RECEPTOR
ALPHA1 ADRENERGIC RECEPTOR
ALPHA2 ADRENERGIC RECEPTOR
H1 HISTAMINERGIC RECEPTOR

D(2) dopamine receptor UNIPROT P14416 DRD2 -- 5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A

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