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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| VORINOSTAT
| VORINOSTAT | ANTINEOPLASTIC AGENTS | ORAL | Cmax 1.2 MICROMOLAR Tmax 4 HOUR VD 32.5 LITER (65 KILOGRAM) PPB 71 PERCENT Cl 109 LITER / HOUR (65 KILOGRAM) HT 2 HOUR SOLUBILITY SLIGHTLY SOLUBLE IN WATER | HISTONE DEACETYLASE PDB 4QA2 (CRYSTAL STRUCTURE OF I243N HDAC8 IN COMPLEX WITH SAHA) LIGAND CODE = SHH (link to the list of PDB complexes) Download experimental 3D coordinates of SHH with added hydrogens | Histone deacetylase 2 UNIPROT Q92769 HDAC2 -- Histone deacetylase 1 UNIPROT Q13547 HDAC1 more at DrugCentral | EMA | |||
