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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| DASATINIB
| DASATINIB | ANTINEOPLASTIC | ORAL | VD 2505 LITER PPB 96 PERCENT Cl 433 LITER / HOUR (EQN) HT 4 HOUR SOLUBILITY INSOLUBLE IN WATER | BCR-ABL ABL1 SRC FAMILY (SRC, LCK, YES, FYN) C-KIT EPHA2 PDGFR BETA PDB 2Y6O (CRYSTAL STRUCTURE OF EPHA4 KINASE DOMAIN IN COMPLEX WITH DASATINIB.) LIGAND CODE = 1N1 (link to the list of PDB complexes) Download experimental 3D coordinates of 1N1 with added hydrogens | Platelet-derived growth factor receptor beta UNIPROT P09619 PDGFRB -- Tyrosine-protein kinase ABL1 UNIPROT P00519 ABL1 more at DrugCentral | EMA | |||
