Browse e-DRUG3D database

Cheminformatic Tools and Databases for Pharmacology
Home	e-Drug3D	LEA3D	SENSAAS	IPMC

session 95891 - Total of 3 hits - Display hits per page:

Add another drug(s) by one keyword:
Exemple: “nib“ and click on the Search button (do not press Enter on the keyboard)


1	INN	Class	Route (list)	PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)	Primary Target and PDB code of Protein-Drug complex	Targets from DrugCentral	Links
M TETRABENAZINE (is an active metabolite)	TETRABENAZINE	ATC N07XX06 NERVOUS SYSTEM CNS TREATMENT OF CHOREA ASSOCIATED WITH HUNTINGTON DISEASE INHIBITOR IS BELIEVED TO BE RELATED TO ITS EFFECT AS A REVERSIBLE DEPLETOR OF MONOAMINES (SUCH AS DOPAMINE, SEROTONIN, NOREPINEPHRINE, AND HISTAMINE) FROM NERVE TERMINALS VESICULAR MONOAMINE TRANSPORTER TYPE 2 (VMAT2) (KI=100 NANOMOLAR)	-	Tmax 1 HOUR PPB 61 PERCENT HT 5 HOUR	VESICULAR MONOAMINE TRANSPORTER TYPE 2 (VMAT2)	Synaptic vesicular amine transporter UNIPROT Q05940 SLC18A2 more at DrugCentral	EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank
2	INN	Class	Route (list)	PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)	Primary Target and PDB code of Protein-Drug complex	Targets from DrugCentral	Links
M TETRABENAZINE (is an active metabolite)	TETRABENAZINE	ATC N07XX06 NERVOUS SYSTEM CNS TREATMENT OF CHOREA ASSOCIATED WITH HUNTINGTON DISEASE INHIBITOR IS BELIEVED TO BE RELATED TO ITS EFFECT AS A REVERSIBLE DEPLETOR OF MONOAMINES (SUCH AS DOPAMINE, SEROTONIN, NOREPINEPHRINE, AND HISTAMINE) FROM NERVE TERMINALS VESICULAR MONOAMINE TRANSPORTER TYPE 2 (VMAT2) (KI=100 NANOMOLAR)	-	Tmax 1 HOUR PPB 64 PERCENT HT 7 HOUR	VESICULAR MONOAMINE TRANSPORTER TYPE 2 (VMAT2)	Synaptic vesicular amine transporter UNIPROT Q05940 SLC18A2 more at DrugCentral	EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank
3	INN	Class	Route (list)	PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)	Primary Target and PDB code of Protein-Drug complex	Targets from DrugCentral	Links
TETRABENAZINE (has an active metabolite)	TETRABENAZINE	ATC N07XX06 NERVOUS SYSTEM CNS TREATMENT OF CHOREA ASSOCIATED WITH HUNTINGTON DISEASE INHIBITOR IS BELIEVED TO BE RELATED TO ITS EFFECT AS A REVERSIBLE DEPLETOR OF MONOAMINES (SUCH AS DOPAMINE, SEROTONIN, NOREPINEPHRINE, AND HISTAMINE) FROM NERVE TERMINALS VESICULAR MONOAMINE TRANSPORTER TYPE 2 (VMAT2) (KI=100 NANOMOLAR)	ORAL	F 75 PERCENT PPB 84 PERCENT SOLUBILITY SPARINGLY SOLUBLE IN WATER	VESICULAR MONOAMINE TRANSPORTER TYPE 2 (VMAT2) PDB 8THR (STRUCTURE OF THE HUMAN VESICULAR MONOAMINE TRANSPORTER 2 (VMAT2) BOUND TO TETRABENAZINE IN AN OCCLUDED CONFORMATION) LIGAND CODE = EBZ (link to the list of PDB complexes) Download experimental 3D coordinates of EBZ with added hydrogens	Synaptic vesicular amine transporter UNIPROT Q05940 SLC18A2 more at DrugCentral	EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank