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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
TIPRANAVIR

TIPRANAVIR


ATC J05AE09

ANTIINFECTIVES
HIV PROTEASE INHIBITOR
ANTIVIRAL

ORAL

Cmax 94.8 MICROMOLAR (500 MILLIGRAM)

Tmax 2.9 HOUR

VD 8.5 LITER

PPB 99.9 PERCENT

Cl 1.15 LITER / HOUR

HT 5.5 HOUR

SOLUBILITY INSOLUBLE IN WATER

HIV-1 PROTEASE

PDB 3SPK (TIPRANAVIR IN COMPLEX WITH A HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE VARIANT)

LIGAND CODE = TPV (link to the list of PDB complexes)

Download experimental 3D coordinates of TPV with added hydrogens

Pol polyprotein UNIPROT Q72874 pol

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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