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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
RAMELTEON

RAMELTEON


ATC N05CH02

NERVOUS SYSTEM
HYPNOTICS
SEDATIVES
TREATMENT OF INSOMNIA
AGONIST

ORAL

Tmax 0.75 HOUR

F 1.8 PERCENT

VD 73.6 LITER

PPB 82 PERCENT

Cl 28.3 LITER / HOUR (EQN)

HT 1.8 HOUR

SOLUBILITY VERY SLIGHTLY SOLUBLE IN WATER

MELATONIN RECEPTOR MT1
MELATONIN RECEPTOR MT2

PDB 6ME2 (XFEL CRYSTAL STRUCTURE OF HUMAN MELATONIN RECEPTOR MT1 IN COMPLEX WITH RAMELTEON)

LIGAND CODE = JEV (link to the list of PDB complexes)

Download experimental 3D coordinates of JEV with added hydrogens

MELATONIN RECEPTOR AGONIST CHEMBL2094268 MELATONIN RECEPTOR P48039 MELATONIN RECEPTOR TYPE 1A HOMO SAPIENS MEMBRANE RECEPTOR 7TM1 SMALLMOL MONOAMINE-DERIVATIVE MELATONIN RECEPTORANSM (in French)

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