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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
ALVIMOPAN

ALVIMOPAN


ATC A06AH02

METABOLISM
MU-TYPE OPIOID ANTAGONIST (KI=0.4 NANOMOLAR)
GASTROINTESTINAL
ANTAGONIZES THE PERIPHERAL EFFECTS OF OPIOIDS

ORAL

Cmax 25.8 NANOMOLAR

Tmax 2 HOUR

F 6 PERCENT

VD 30 LITER

PPB 87 PERCENT

Cl 24 LITER / HOUR

HT 14 HOUR

SOLUBILITY LESS THAN 0.1 MILLIGRAM / MILLILITER IN WATER

MU-TYPE OPIOID RECEPTOR

MU OPIOID RECEPTOR ANTAGONIST CHEMBL233 MU OPIOID RECEPTOR P35372 MU-TYPE OPIOID RECEPTOR HOMO SAPIENS MEMBRANE RECEPTOR 7TM1 PEPTIDE SHORT PEPTIDE OPIOID RECEPTORANSM (in French)

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