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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
DYPHYLLINE DISCONTINUED

DYPHYLLINENATURAL MOLECULE (link)


ATC R03DA01
ATC R03DB01
ATC R03DA51

RESPIRATORY
BRONCHODILATOR AGENTS
PHOSPHODIESTERASE INHIBITORS
SMOOTH MUSCLE RELAXANTS
VASODILATOR AGENTS

ORAL INJECTION

Cmax 67 MICROMOLAR

VD 27.3 LITER (65 KILOGRAM)

Cl 18.7 LITER / HOUR (65 KILOGRAM)

HT 2 HOUR

SOLUBILITY FREELY SOLUBLE IN WATER

PHOSPHODIESTERASE

PDB 2X0Y (SCREENING-BASED DISCOVERY OF DRUG-LIKE O-GLCNACASE INHIBITOR SCAFFOLDS)

LIGAND CODE = X0T (link to the list of PDB complexes)

Download experimental 3D coordinates of X0T with added hydrogens

cGMP-inhibited 3,5-cyclic phosphodiesterase A UNIPROT Q14432 PDE3A -- cAMP-specific 3,5-cyclic phosphodiesterase 4B UNIPROT Q07343 PDE4B

more at DrugCentral

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ANSM (in French)

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ChEMBL
BindingDB
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