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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| CINACALCET
| CINACALCET | HORMONES | ORAL | Tmax 4 HOUR VD 1000 LITER PPB 95 PERCENT Cl 19.8 LITER / HOUR (EQN) HT 35 HOUR SOLUBILITY SLIGHTLY SOLUBLE IN WATER | EXTRACELLULAR CALCIUM-SENSING RECEPTOR PDB 7M3F (ASYMMETRIC ACTIVATION OF THE CALCIUM SENSING RECEPTOR HOMODIMER) LIGAND CODE = YP4 (link to the list of PDB complexes) Download experimental 3D coordinates of YP4 with added hydrogens | Extracellular calcium-sensing receptor UNIPROT P41180 CASR more at DrugCentral | EMA | |||
