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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| BROMFENAC
| BROMFENAC | SENSORY | OPHTHALMIC | VD 7.15 LITER (65 KILOGRAM) PPB 99 PERCENT Cl 5 LITER / HOUR (65 KILOGRAM) HT 2.6 HOUR | PROSTAGLANDIN G/H SYNTHASE 1 PROSTAGLANDIN G/H SYNTHASE 2 PDB 4MJQ (E. COLI SLIDING CLAMP IN COMPLEX WITH BROMFENAC) LIGAND CODE = 27R (link to the list of PDB complexes) Download experimental 3D coordinates of 27R with added hydrogens | Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 -- Prostaglandin G,H synthase 1 UNIPROT P23219 PTGS1 more at DrugCentral | EMA | |||
