Cheminformatic Tools and Databases for Pharmacology

session 89066 - Total of 2 hits - Display   hits per page:

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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
CICLESONIDE (has an active metabolite)

CICLESONIDE


ATC R03BA08
ATC R01AD13

RESPIRATORY
ANTIINFLAMMATORY
ANTI-ALLERGIC AGENTS
GLUCOCORTICOIDS

INHALATION NASAL

F 22 PERCENT

VD 188 LITER (65 KILOGRAM)

PPB 99 PERCENT

Cl 152 LITER / HOUR

HT 0.71 HOUR

CORTICOSTEROID-BINDING GLOBULIN

GLUCOCORTICOID RECEPTOR AGONIST CHEMBL2034 GLUCOCORTICOID RECEPTOR P04150 GLUCOCORTICOID RECEPTOR HOMO SAPIENS TRANSCRIPTION FACTOR NUCLEAR RECEPTOR NR3 NR3C NR3C1ANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank

2 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
M CICLESONIDE (is an active metabolite)

CICLESONIDE


ATC R03BA08
ATC R01AD13

RESPIRATORY
ANTIINFLAMMATORY
ANTI-ALLERGIC AGENTS
GLUCOCORTICOIDS

-

Cmax 2.17 NANOMOLAR

Tmax 1.04 HOUR

F 63 PERCENT

VD 786 LITER (65 KILOGRAM)

PPB 99 PERCENT

Cl 228 LITER / HOUR

HT 6.5 HOUR

CORTICOSTEROID-BINDING GLOBULIN

PDB 4UDD (GR IN COMPLEX WITH DESISOBUTYRYLCICLESONIDE)

LIGAND CODE = CV7 (link to the list of PDB complexes)

Download experimental 3D coordinates of CV7 with added hydrogens

GLUCOCORTICOID RECEPTOR AGONIST CHEMBL2034 GLUCOCORTICOID RECEPTOR P04150 GLUCOCORTICOID RECEPTOR HOMO SAPIENS TRANSCRIPTION FACTOR NUCLEAR RECEPTOR NR3 NR3C NR3C1ANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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