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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| CICLESONIDE (has an active metabolite)
| CICLESONIDE | RESPIRATORY | INHALATION NASAL | F 22 PERCENT VD 188 LITER (65 KILOGRAM) PPB 99 PERCENT Cl 152 LITER / HOUR HT 0.71 HOUR | CORTICOSTEROID-BINDING GLOBULIN | Glucocorticoid receptor UNIPROT P04150 NR3C1 more at DrugCentral | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| M CICLESONIDE (is an active metabolite)
| CICLESONIDE | RESPIRATORY | - | Cmax 2.17 NANOMOLAR Tmax 1.04 HOUR F 63 PERCENT VD 786 LITER (65 KILOGRAM) PPB 99 PERCENT Cl 228 LITER / HOUR HT 6.5 HOUR | CORTICOSTEROID-BINDING GLOBULIN PDB 4UDD (GR IN COMPLEX WITH DESISOBUTYRYLCICLESONIDE) LIGAND CODE = CV7 (link to the list of PDB complexes) Download experimental 3D coordinates of CV7 with added hydrogens | Glucocorticoid receptor UNIPROT P04150 NR3C1 more at DrugCentral | EMA | |||
