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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
BORTEZOMIB

BORTEZOMIB


ATC L01XX32

ANTINEOPLASTIC AGENTS
PROTEASE INHIBITORS

INTRAVENOUS SUBCUTANEOUS INJECTION

Cmax 321.7 NANOMOLAR

VD 1917 LITER

PPB 83 PERCENT

Cl 32 LITER / HOUR

HT 92 HOUR

26S PROTEASOME

PDB 4QW1 (YCP BETA5-A50V MUTANT IN COMPLEX WITH BORTEZOMIB)

LIGAND CODE = BO2 (link to the list of PDB complexes)

Download experimental 3D coordinates of BO2 with added hydrogens

26S PROTEOSOME INHIBITOR CHEMBL2364701 26S PROTEOSOME P28074 PROTEASOME SUBUNIT BETA HOMO SAPIENS ENZYME PROTEASE THREONINE PBT T1AANSM (in French)

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