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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| RANOLAZINE
| RANOLAZINE | CARDIOVASCULAR | ORAL | Cmax 6.08 MICROMOLAR Tmax 3.5 HOUR F 76 PERCENT PPB 62 PERCENT HT 7 HOUR SOLUBILITY VERY SLIGHTLY SOLUBLE IN WATER | VOLTAGE-GATED NA(+) CHANNELS (NAV) (PMID26655634) ALPHA1-ADRENERGIC RECEPTOR (PMID26655634) PDB 8F6P (RAT CARDIAC SODIUM CHANNEL WITH RANOLAZINE BOUND) LIGAND CODE = XHO (link to the list of PDB complexes) Download experimental 3D coordinates of XHO with added hydrogens | Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A more at DrugCentral | EMA | |||
