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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
RANOLAZINE

RANOLAZINE


ATC C01EB18

CARDIOVASCULAR
ANTIANGINAL
TREATMENT OF CHRONIC ANGINA
INHIBIT THE CARDIAC LATE SODIUM CURRENT
VOLTAGE-GATED NA(+) CHANNELS (NAV) INHIBITOR
ALPHA1-ADRENERGIC RECEPTOR ANTAGONIST (PMID26655634)

ORAL

Cmax 6.08 MICROMOLAR

Tmax 3.5 HOUR

F 76 PERCENT

PPB 62 PERCENT

HT 7 HOUR

SOLUBILITY VERY SLIGHTLY SOLUBLE IN WATER

VOLTAGE-GATED NA(+) CHANNELS (NAV) (PMID26655634)
ALPHA1-ADRENERGIC RECEPTOR (PMID26655634)

SODIUM CHANNEL PROTEIN TYPE IV ALPHA SUBUNIT BLOCKER CHEMBL2072 SODIUM CHANNEL PROTEIN TYPE IV ALPHA SUBUNIT P35499 SODIUM CHANNEL PROTEIN TYPE 4 SUBUNIT ALPHA HOMO SAPIENS ION CHANNEL VGC VG NAANSM (in French)

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