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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| NITAZOXANIDE (has an active metabolite)
| NITAZOXANIDE | ANTIPARASITIC | ORAL | F 70 PERCENT SOLUBILITY PRATICALLY INSOLUBLE IN WATER | PYRUVATE:FERREDOXIN OXIDOREDUCTASE PDB 3V35 (ALDOSE REDUCTASE COMPLEXED WITH A NITRO COMPOUND) LIGAND CODE = NTI (link to the list of PDB complexes) Download experimental 3D coordinates of NTI with added hydrogens | Pyruvate dehydrogenase NADP(+) UNIPROT Q968X7 PFOR -- Pyruvate:ferredoxin oxidoreductase UNIPROT Q24982 more at DrugCentral | EMA | |||
