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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
PREGABALIN

PREGABALIN


ATC N03AX16

NERVOUS SYSTEM
ANALGESICS
ANTICONVULSANTS
NEUROPATHIC PAIN

ORAL

Tmax 1.5 HOUR

F 90 PERCENT

VD 32.5 LITER (65 KILOGRAM)

PPB 0 PERCENT

Cl 3.7 LITER / HOUR (EQN)

HT 6 HOUR

SOLUBILITY FREELY SOLUBLE IN WATER

ALPHA2-DELTA SITE OF VOLTAGE-GATED CALCIUM CHANNEL

PDB 3JBR (CRYO-EM STRUCTURE OF THE RABBIT VOLTAGE-GATED CALCIUM CHANNEL CAV1.1 COMPLEX AT 4.2 ANGSTROM)

VOLTAGE-GATED CALCIUM CHANNEL MODULATOR CHEMBL2363032 VOLTAGE-GATED CALCIUM CHANNEL P54289 VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-1 HOMO SAPIENS AUXILIARY TRANSPORT PROTEIN CA ALPHA2DELTAANSM (in French)

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