| | ||||||||||
| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| EZETIMIBE
| EZETIMIBE |
CARDIOVASCULAR | ORAL | Cmax 13.4 NANOMOLAR Tmax 8 HOUR PPB 90 PERCENT HT 22 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | NIEMANN-PICK C1-LIKE PROTEIN 1 (NPC1L1) PDB 8AXW (THE STRUCTURE OF MOUSE ASTERC (GRAMD1C) WITH EZETIMIBE) LIGAND CODE = H56 (link to the list of PDB complexes) Download experimental 3D coordinates of H56 with added hydrogens | Niemann-Pick C1-like protein 1 UNIPROT Q9UHC9 NPC1L1 more at DrugCentral | EMA | |||
