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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ARIPIPRAZOLE (is an active metabolite)
| ARIPIPRAZOLE | NERVOUS SYSTEM | ORAL INTRAMUSCULAR | Tmax 4 HOUR F 87 PERCENT VD 404 LITER PPB 99 PERCENT Cl 3.2 LITER / HOUR (65 KILOGRAM) HT 75 HOUR | 5-HYDROXYTRYPTAMINE 1A RECEPTOR 5-HYDROXYTRYPTAMINE 2A RECEPTOR D2 DOPAMINE RECEPTOR ADRENERGIC ALPHA1 RECEPTOR PDB 6A7P (HUMAN SERUM ALBUMIN COMPLEXED WITH ARIPIPRAZOLE) LIGAND CODE = 9SC (link to the list of PDB complexes) Download experimental 3D coordinates of 9SC with added hydrogens | D(2) dopamine receptor UNIPROT P14416 DRD2 -- 5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A more at DrugCentral | EMA | |||
