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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
THEOPHYLLINE

THEOPHYLLINE
AMINOPHYLLINE
NATURAL MOLECULE (link)


ATC R03DA04
ATC R03DB04
ATC R03DA54
ATC R03DA74

RESPIRATORY SYSTEM
SMOOTH MUSCLE RELAXANT
CARDIOTONIC
BRONCHODILATOR AGENTS
PHOSPHODIESTERASE INHIBITORS
VASODILATOR AGENTS
AMINOPHYLLINE IS THEOPHYLLINE WITH 1,2-ETHANEDIAMINE (2:1)

ORAL RECTAL INJECTION

VD 29.2 LITER (65 KILOGRAM)

PPB 40 PERCENT

Cl 2.5 LITER / HOUR (65 KILOGRAM)

HT 8.7 HOUR

PHOSPHODIESTERASE III
PHOSPHODIESTERASE IV

PDB 1EHT (THEOPHYLLINE-BINDING RNA IN COMPLEX WITH THEOPHYLLINE, NMR, 10 STRUCTURES)

LIGAND CODE = TEP (link to the list of PDB complexes)

Download experimental 3D coordinates of TEP with added hydrogens

Adenosine receptor A2a UNIPROT P29274 ADORA2A -- cGMP-inhibited 3,5-cyclic phosphodiesterase A UNIPROT Q14432 PDE3A

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
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Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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