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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
ACAMPROSATE

ACAMPROSATE


ATC N07BB03

NERVOUS SYSTEM
MAINTENANCE OF ABSTINENCE OF ALCOHOL
CHEMICAL STRUCTURE SIMILAR TO THAT OF THE ENDOGENOUS AMINO ACID HOMOTAURINE
MAY INTERACT WITH GLUTAMATE AND GABA NEUROTRANSMITTER SYSTEMS CENTRALLY

ORAL

Tmax 5.5 HOUR

F 11 PERCENT

VD 90.5 LITER

PPB 0 PERCENT

Cl 2.3 LITER / HOUR (EQN)

HT 26.5 HOUR

SOLUBILITY FREELY SOLUBLE IN WATER

GABA-A receptor alpha-1,beta-3,gamma-2 UNIPROT P14867 GABRA1 -- Glutamate NMDA receptor UNIPROT O15399 GRIN2D

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