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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| DULOXETINE
| DULOXETINE | NERVOUS SYSTEM | ORAL | Tmax 6 HOUR VD 1640 LITER PPB 90 PERCENT Cl 94.7 LITER / HOUR (EQN) HT 12 HOUR SOLUBILITY SLIGHTLY SOLUBLE IN WATER | SEROTONIN TRANSPORTER NOREPINEPHRINE TRANSPORTER PDB 4MMD (CRYSTAL STRUCTURE OF LEUBAT (DELTA6 MUTANT) IN COMPLEX WITH (S)-DULOXETINE) LIGAND CODE = 29E (link to the list of PDB complexes) Download experimental 3D coordinates of 29E with added hydrogens | Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 -- Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 more at DrugCentral | EMA | |||
