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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
PALONOSETRON

PALONOSETRON


ATC A04AA05
ATC A04AA55

METABOLISM
ANTIEMETIC
SEROTONIN 5-HT3 RECEPTOR ANTAGONIST
PREVENT NAUSEA AND VOMITING

INTRAVENOUS ORAL INJECTION

Cmax 18.9 NANOMOLAR

Tmax 5.1 HOUR

F 97 PERCENT

VD 539.5 LITER (65 KILOGRAM)

PPB 62 PERCENT

Cl 10.4 LITER / HOUR (65 KILOGRAM)

HT 40 HOUR

SOLUBILITY FREELY SOLUBLE IN WATER

5-HYDROXYTRYPTAMINE 3 RECEPTOR

PDB 6Y1Z (MOUSE SEROTONIN 5HT3 RECEPTOR IN COMPLEX WITH PALONOSETRON)

LIGAND CODE = O7B (link to the list of PDB complexes)

Download experimental 3D coordinates of O7B with added hydrogens

SEROTONIN 3A (5-HT3A) RECEPTOR ANTAGONIST CHEMBL1899 SEROTONIN 3A (5-HT3A) RECEPTOR P46098 5-HYDROXYTRYPTAMINE RECEPTOR 3A HOMO SAPIENS ION CHANNEL LGIC 5HT3ANSM (in French)

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